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Test for roan RELEASED!!!!!!!

Ok, well it's a haplotype test, and it apparently only works on Quarter Horses and Paints (implying to me that there may be multiple roan mutations): http://www.vgl.ucdavis.edu/services/Roan.php" onclick="window.open(this.href);return false; I'm sure Horsegen will be here to enlighten us at some point. :bounce :bounce :bounce

Sara Mon, 04/20/2009 - 12:21

Verrrrrry interesting! Different roan mutations would be weird because roan looks pretty much the same in all breeds. A roan Welsh has the same distribution of white in its coat as a roan QH. Multiple mutations makes loads of sense for something like sabino with all its variations, but I'm very eager to hear the explanation on roan.

accphotography Mon, 04/20/2009 - 12:26

Don't forget Dominant White and it's four mutations (conveniently located on the same chromosome and even in the same region as roan) apparently have the same phenotype. That certainly implies KIT is a region VERY apt to mutate. Tobiano, roan1 (and who knows how many others), dominant white x4+, sabino1 (and who knows how many others). And of course the coolest part of all of that IMO is that they are all linked to extension (and each other as well).

RiddleMeThis Mon, 04/20/2009 - 12:43

The TB roans are also interesting as they are almost certainly their own mutation, and possibly in a completely different location than KIT as they dont follow the E and KIT connection, but they could have been one of the small cross over percentages.

Sara Mon, 04/20/2009 - 16:02

ACC, I said Catch a Bird "type" - I mean the ones marked more like him, which were the ones I saw first. :)

Monsterpony, I bet the Shetland and Welsh roans will test the same. I have not heard of any roan Welsh stallions who pass it on 100% of the time either. Lewella's data convinced me that it is homozygous embryonic lethal, at least where Shetlands are concerned.

RiddleMeThis Mon, 04/20/2009 - 16:08

[quote="Sara"]ACC, I said Catch a Bird "type" - I mean the ones marked more like him, which were the ones I saw first. :)
[/quote]
Catch a Bird is brindled, not roaned...I have no idea what you mean about "catch a bird type."

accphotography Mon, 04/20/2009 - 16:12

[quote="Monsterpony"]I wonder about the shetland roan since there seemed to be breeding evidence that is was not viable in homozygous form.[/quote]

There was also evidence in Brabants.

rabbitsfizz Tue, 04/21/2009 - 04:30

Some of the Belgian (Brabant) bloodlines I was [i]told,[/i] are H/Z but the person I was talking to did not have the proof, he had heard it from someone else....now these were BIG Belgian breeders (in Belgium, where the Chestnuts are relatively unusual) and as he pointed out, when the end result is the Sunday roast you are not that bothered about the colour it was originally......
The only thing that indicated to both of us that this might be correct is that a couple of the horse he mentioned had only Roans, and if the mares had not taken (ie if the embryo were not viable) they very quickly would not have bred her to that stallion again as a foal a year is the object.
As you know I do think Roan can be lethal in H/Z but I do not think it is breed distinctive and I think we may be dealing with a partial lethal as it would appear to be in Fewspots...a theory I might add that was openly laughed at on this Forum when I first suggested it and is now being considered by geneticists!!!!

accphotography Tue, 04/21/2009 - 19:27

[quote="rabbitsfizz"]
As you know I do think Roan can be lethal in H/Z but I do not think it is breed distinctive and I think we may be dealing with a partial lethal as it would appear to be in Fewspots...a theory I might add that was openly laughed at on this Forum when I first suggested it and is now being considered by geneticists!!!![/quote]

I've never heard that. Can you shed any more light on it?

NZ Appaloosas Tue, 04/21/2009 - 20:07

Me too...the only "bad" connection I've heard in relation to fewspots/snowcaps is the CNSB one. And I know a lot of people are on the fence about that, citing owning LpLP horses with no vision problems, small # of horses in study, no info regarding connectivity as to relation of horses in study to each other, etc.

Diane

dakotakdq Tue, 04/21/2009 - 23:11

Id like to see proof that a homo roan is a lethal. Seen a few roans here that have 100% roan foals (one was a QH sire with over 15-25 roan babies) so they are 'assumed' to be homo for roan, thou of course not proven. il have to contact one of them I know about the new roan test, be very exciting to see the reults thats for sure :)

Sara Tue, 04/21/2009 - 23:52

ACC, your photos didn't show up for me before so I couldn't respond but now I can see them and no, those aren't the ones I remember. so either it's something else or I'm just... confused... which is entirely possible in my sleep deprived state!

I do have a theory about (non-chimeric) brindles though. It's similar to the speculation that many horses have primitive markings but we can only sometimes see them -- like every spring Ginny goes through a sooty phase and gets full on primitive markings. She didn't get the zebra striped legs this year but she has the dorsal stripe and shoulder shading. it's obvious enough that a student who is only 8 or 9 asked why her back is black right now.

Anyway I think many horses have the *possibility* for brindle markings but need some sort of color to turn it on or make it visible. I've seen a couple horses with self colored stripes just where you would expect brindle to be. They make the horse look ribby in certain lights but if you get close and feel the horse, you can tell it's just a hair pattern. Anyway, I think that something that "turns on" dark hairs (i.e. sooty) or white hairs (rabicano, sabino, or roan) will then fall into the brindle pattern on horses who are predisposed to it. So then yes, it makes sense that brindle and roan are appearing in the same family line.

PamelaTX Wed, 04/22/2009 - 00:39

[color=#8000BF][b]Interesting!! I've been waiting for this.
But what if you're unable to get hair from either the sire or dam for the test??
Can the test still be done?
Not many would have access to the parents hairs.[/b][/color]

Dogrose Wed, 04/22/2009 - 08:04

You would need data on more than 20 foals to know if a parent was homozygous for a dominant colour. I breed fancy rats and its quite possible for heterozygous parents of a dominant colour or one heterozygous dominant and one homozygous recessive to have a whole litter, say 16 babies, of the one dominant colour despite the expected being some recessives. I think its reckoned you need data from at least 100 offspring to be sure.
Hope that made sense :|

accphotography Wed, 04/22/2009 - 11:16

[quote="Sara"]ACC, your photos didn't show up for me before so I couldn't respond but now I can see them and no, those aren't the ones I remember. so either it's something else or I'm just... confused... which is entirely possible in my sleep deprived state!

I do have a theory about (non-chimeric) brindles though. It's similar to the speculation that many horses have primitive markings but we can only sometimes see them -- like every spring Ginny goes through a sooty phase and gets full on primitive markings. She didn't get the zebra striped legs this year but she has the dorsal stripe and shoulder shading. it's obvious enough that a student who is only 8 or 9 asked why her back is black right now.

Anyway I think many horses have the *possibility* for brindle markings but need some sort of color to turn it on or make it visible. I've seen a couple horses with self colored stripes just where you would expect brindle to be. They make the horse look ribby in certain lights but if you get close and feel the horse, you can tell it's just a hair pattern. Anyway, I think that something that "turns on" dark hairs (i.e. sooty) or white hairs (rabicano, sabino, or roan) will then fall into the brindle pattern on horses who are predisposed to it. So then yes, it makes sense that brindle and roan are appearing in the same family line.[/quote]

I think your theory holds water. I've seen rib stripes on Lacy when I couldn't even FEEL her ribs, much less see them.
This is definitely color/texture, NOT ribs (ignore the arrows, I'm talking about the ribs):
[img]http://i173.photobucket.com/albums/w65/…]

Well they did prove Catch a Bird was chimeric. It is possible that his twin had a roan mutation thus causing the twin's areas to be white. However, since roan is seasonal, I would have thought his stripes would have been as well and I've never heard that they were. I'm not sure. He was such an oddity in so many ways.

Sara Wed, 04/22/2009 - 11:38

Yes, that photo of Lace is exactly what I mean. The Haflinger in my barn has it too and she's definitely not underweight.

Hmm, I had forgotten that CAB was a chimera. He really was an odd one!

Danni Sun, 05/03/2009 - 05:16

So has anyone heard if the test ONLY works for QH's and Paints? Or can any true/classic roan be tested with this and they are just using the QH and Paint definition to explain which roan they are talking about??
Cheers

Danni

Dilutes Sun, 05/03/2009 - 09:32

My buckskin gets those rib type marks and has had me scratching my head as he looks good and feels good when running my hand along there but sometimes in certain light he'll get those rib marks. I hate it when it shows in photos as I know he isn't ribby and has a nice topline and rump.

rabbitsfizz Sun, 05/03/2009 - 11:42

I am wondering about that....why on earth would a breed test differently??
Maybe it isn't Roan, maybe it is a whole new mutation that is only in QH's and also therefore, Paints????
H/Z Roan shows it is lethal merely by foals not being born, do we really have to keep explaining that or is it OK to assume everyone realises that??
25 foals is nowhere near enough to prove Homozygosity, call me when the horse has had 50 Roan foals out of non- Roan mares, and I might pay attention!!
That's the problem, people think that because there horse has thrown a whole ten foals of a particular colour or pattern it is H/Z...oh dear!!

Diane, I will try to get back to the Fewspot thing when that part of my brain comes back on line....do NOT hold your breathe it may be a while :sign

accphotography Sun, 05/03/2009 - 11:54

[quote="rabbitsfizz"]I am wondering about that....why on earth would a breed test differently??
Maybe it isn't Roan, maybe it is a whole new mutation that is only in QH's and also therefore, Paints????
H/Z Roan shows it is lethal merely by foals not being born, do we really have to keep explaining that or is it OK to assume everyone realises that??
25 foals is nowhere near enough to prove Homozygosity, call me when the horse has had 50 Roan foals out of non- Roan mares, and I might pay attention!!
That's the problem, people think that because there horse has thrown a whole ten foals of a particular colour or pattern it is H/Z...oh dear!![/quote]

Try 100+. Some of the Hancock roans have had 100+ roan foals. That's no coincidence.

Yes, it is perfectly plausible it's a separate mutation of roan and is thus different from breed to breed. There are 4 separate mutations of dominant white after all (which is harbored in the same gene as this roan).

No, not everyone "realizes" it's a homozygous lethal. Some of us, in fact, do not even believe it is.

rabbitsfizz Sun, 05/03/2009 - 14:42

Yes, I know about the Hancocks, which is what got me wondering about it being something else, maybe not Roan...and now we see that it only tests in QH's and derivatives thereof...see what I mean??

Sara Sun, 05/03/2009 - 18:57

Yep, what rabbit says is what I think. The Hancock line just must have something else going on. If homozygous roan is as possible as homozygous tobiano or other simple dominants, there would be loads of them from many lines and many breeds. That alone is enough to send off warning alarms to me.