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Not that it will surprise anyone, but... new DW mutation...

accphotography December 17, 2010 February 22, 2011

Forums

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2052.2010.02135.x/full" onclick="window.open(this.href);return false; I'm certain anyone here would have had no doubts what they would discover this colt was. Maybe this will help some people (not here) realize that mutations DO occur, quite frequently. So we're up to 12 mutations so far and I have ZERO doubt there will be dozens more found.

Threnody Sat, 12/18/2010 - 13:15

They found a gastric ulcer along with some other problems it seems. They state that gastric ulcers have occurred in mice and humans caused by KIT mutations, but it is inconclusive if it was caused by the new mutation. There may have been another allele present that the new mutation interacted with to cause the problems the foal had.

However if W12 was in actuality a dominant lethal trait it terminated with the founding animal. Poor thing. :sad:

TheRedHayflinger Sun, 12/19/2010 - 13:41

couldn't resist! hehe

you know that big belgian I used to own that looked DW-ish? She's looking for a retirement home last I tracked her down..and she's free...anyone lookin' for a big, gorgeous Belgian that probably has at least splash (she has a blue eye)...lol

accphotography Sun, 12/19/2010 - 19:49

Oh I think there are hundreds of them. I have seen an uncountable number of horses who appear to carry a DW mutation but don't come from known (yet) DW lines. I think some are perfectly viable (at least in heterozygous form) and some just aren't. I'd bet there have been a good number of DW foals who were not truly viable mistaken for LWO foals or even somewhat longer than usual living LWO foals.

tjuri Tue, 12/28/2010 - 13:36

Here is a review from thehorse.com.
http://www.thehorse.com/ViewArticle.asp…" onclick="window.open(this.href);return false;

"Dominant white cases are rare, as the gene for the white coat color is usually a recessive trait. When a horse has one dominant white gene, the result will be a pure white horse that lacks pigment in the skin from birth. Historically, two dominant white genes have proved lethal for foals, generally within 48 hours of birth."

I think at the end of the article the author falls victim to some confusion and is mixing up LWO with Dominant White since I remember homozygous DW causes an intra-uterine lethal foal, not a foal that is actually born and then dies within 48 hours? :?

Threnody Tue, 12/28/2010 - 14:50

[quote="tjuri"]Here is a review from thehorse.com.
http://www.thehorse.com/ViewArticle.asp…" onclick="window.open(this.href);return false;

"Dominant white cases are rare, as the gene for the white coat color is usually a recessive trait. When a horse has one dominant white gene, the result will be a pure white horse that lacks pigment in the skin from birth. Historically, two dominant white genes have proved lethal for foals, generally within 48 hours of birth."

I think at the end of the article the author falls victim to some confusion and is mixing up LWO with Dominant White since I remember homozygous DW causes an intra-uterine lethal foal, not a foal that is actually born and then dies within 48 hours? :?[/quote]

Wow yah. You hit the nail on the head with them mixing up Frame and Dominant White. That is a shame since The Horse in general has some very good information. I don't think the writer of the article understood the subject. The fact that they are claiming it to be recessive when dominant is in the name is also a pretty big mix up.

Threnody Tue, 12/28/2010 - 16:17

Sent them an email about the errors in the article and got a response immediately. Not a pre-made automatically sent out email either. :smile: The person who contacted me stated they are going to look further into possible errors in the article.

Threnody Wed, 12/29/2010 - 21:15

Well they fixed it and took out the LWO mix up, but I disagree with the generalization that dominant white horses are all white. We have plenty of examples where they aren't. The foal itself in the article wasn't all white, so that is a direct contradiction to that statement.

[b]Quote: [/b] [i]When a horse has one dominant white gene, the result will be a pure white horse that lacks pigment in the skin from birth, so they are easy to detect.[/i]

Threnody Thu, 12/30/2010 - 15:29

Just sent out an email. I hate seeming like a nitpicker :? I'm on a different computer than usual so I couldn't send direct images. I sent the URL to the Dun Central Station PDF that has all the pictures of non snow white DW horses.

[quote="Jenks"]Send them a few photos of those that tested positive or that were in the study.... LOL

They will be offering you a consulting job here shortly....[/quote]
Lol. I can dream ^_^

With all the DW mutations I want to see the Airdrie Apache line and the TB family ACC found to get tested. (Speaking of, she seriously needs to become the official scout for DW mutations for the research teams working on this)

Threnody Fri, 12/31/2010 - 16:13

And we have victory! :-D

[b]Quote:[/b]
[i]"KIT mutations cause abnormal melanocytes that do not produce pigment in the skin," explained Heather Holl, BSc, a PhD student in the Department of Animal Science at Cornell University. "The result is horses with pink skin and white hair. The amount of affected skin varies and ranges from small patches of depigmentation to white over the entire body."

To date, researchers have identified 14 different mutations involving the equine KIT gene, including the Sabino-1 and Tobiano color patterns.
[/i]
Less than a day later and the rest of the article looks good too. :smile:

And thanks tjuri. ^_^ I'm just glad they listen to their readers and took a closer look.