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Hmm, New test for Chestnut?????

Just got this from the Horse.Com http://www.thehorse.com/ViewArticle.aspx?ID=15573" onclick="window.open(this.href);return false; http://www.biomedcentral.com/1756-0500/2/255" onclick="window.open(this.href);return false; & a link to the whole article. http://www.biomedcentral.com/content/pdf/1756-0500-2-255.pdf" onclick="window.open(this.href);return false; I haven't read through it, but I thought we already had a test for chestnut & what is ea??? :?: :?: :?: :?:

accphotography Thu, 01/07/2010 - 16:39

We had a test for 'e/E', but we didn't have a test available to the public for 'ea', although I do know that at at least one lab you could specifically request them check for 'ea'.

The two biggest differences in the new test are that it tests for 'ea' and that it uses SNP technology (which is going to take over the world :lol: ). 'ea' is another allele of extension that disable eumalanin, thus making a red horse. Our previous extension test didn't test for it automatically and thus you could end up with a VERY red phenotype testing 'E'.

thorwood Thu, 01/07/2010 - 17:05

:rofl Thanks ACC.

I figured it was different technology, but today being in a lazy mood & couldn't be bothered to read (sigh, I have to go out in the heat & bring in 400 bales of hay), I figured someone here would explain it to me.

I hadn't heard of ea before.

rabbitsfizz Fri, 01/08/2010 - 11:01

[quote="thorwood"]:rofl Thanks ACC.

I figured it was different technology, but today being in a lazy mood & couldn't be bothered to read (sigh, I have to go out in the heat & bring in 400 bales of hay), I figured someone here would explain it to me.

I hadn't heard of ea before.[/quote]
I'm very sorry but, as I am currently suffering (and I [i]am[/i]suffering, believe me!) form two possibly three cracked ribs courtesy of approx. one foot of bloody snow, I am just not in the mood to feel sorry for your having to go out in the [i]heat[/i]!! :booty

Is it visually different, ACC?

accphotography Fri, 01/08/2010 - 13:00

I've never laid eyes on one personally (that I'm AWARE of anyway), but I'm told by a researcher that they're identical. However, I would not be surprised if we had a bunch to compare we might think we could spot some differences, but I kinda doubt it as it does the same thing 'e' does in that it turns off eumelanin resulting in a switch to the default pheomelanin.

DRATS!!! I found their example photos from the article, but the stupid PDF the 'eea' and 'eaea' examples are missing!!! *GAH!!!*

lillith Sat, 01/09/2010 - 04:57

Did they have to use 'a' ? oh confusing. So you could have an E/ea A/a horse? I'm gonna get lost with this. lol.

Has it got the same mechanism as e? so E/ea would be black and ea/ea would be red as would e/ea? And on the normal test it tests as E (i.e. 'not e') so you can get an E/E testing very red looker that would test ea/ea with this new one? which i would imagine would also test E/e horses as such as well?

Monsterpony Sat, 01/09/2010 - 14:12

Actually, the ea test is not new. That second allele was found shortly after the release of the original extension test and all the extension tests available right now test for both e and ea already. What they are calling new is the SNP test, which is how they are doing the genetic test. Other researchers have designed SNP tests (such as the researchers with the VeriSNP test).

accphotography Sat, 01/09/2010 - 14:52

Not U of KY. They told me they didn't test for 'ea' unless it was requested. They also gave me the impression that was the case with most labs.

colorfan Sun, 01/10/2010 - 19:35

In non color terms there is a new test that is more efficient than the old test?
Would accurate be a better term?

Does this test test for various colors simultaneouly or is there a test for each allele?

So the new 'a' restricts agouti just like 'e'. (I agree couldn't they have picked a different letter- I thought one copy of agouti was 'a')

Could this 'a' be responsible for some of the shade variants?

accphotography Sun, 01/10/2010 - 20:40

[quote="colorfan"]In non color terms there is a new test that is more efficient than the old test?
Would accurate be a better term?

Does this test test for various colors simultaneouly or is there a test for each allele?

So the new 'a' restricts agouti just like 'e'. (I agree couldn't they have picked a different letter- I thought one copy of agouti was 'a')

Could this 'a' be responsible for some of the shade variants?[/quote]

I doubt it's more accurate, I think it's just requires fewer steps or something, thus making it more efficient for the lab.

Right now it tests for each allele I believe. But several labs are looking into developing a test that would test for *everything* simultaneously.

Yes, 'eaea' looks exactly like 'ee' and 'Eea' looks exactly like 'Ee'. One copy of [i]recessive[/i] agouti is 'a' (essentially the agouti negative allele). It's important to note that the 'a' in this case will ALWAYS be tied to the 'e'... in other words it's not 'ee a', it's 'eea'. So a horse carrying this allele and no agouti would be 'eea aa'. Or another would be 'Eea Aa'.

Supposedly there are no visible differences, but who could account for shade? It would all be considered "normal". *shrugs* However, given this allele is apparently very rare, I doubt it.

HTH

Songcatcher Tue, 02/23/2010 - 17:48

[quote="accphotography"][quote="colorfan"]
Right now it tests for each allele I believe. But several labs are looking into developing a test that would test for *everything* simultaneously.

HTH[/quote][/quote]
I am so looking forward to such a test. BUT, I'm sure going to be careful about recommending it to anyone like I did with that last one. I had to go crawl under a rock about that.

accphotography Tue, 02/23/2010 - 19:02

Yeah I know... I did the same thing. Too bad they were such a disappointment.

However, if UC Davis or Animal Genetics releases a test like this I will be shouting it from the roof tops. I trust those two labs unequivocally, even with new technology.